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Figure 722 Lipophilic nature of membrane retention, log(%R) versus octanol water apparent partition coef cient, pH 74, neutral lipid models

Goals Strategic alignment Value delivery Risk management Resource management Performance measurement Maturity Models

corresponding to where log Kd is zero (approximately equal to the Pe of metoprolol in 2% DOPC) Although the scatter of points is considerable, the pattern of the relationship between log Pe and log Kd best resembles the hyperbolic plot in Fig 719b, with diffusion-limited (UWL) permeabilities for log Kd > 2 and membrane-limited permeabilities for log Kd < 1 (We discuss the UWL further Section 776)

Policies The company needs to make policies about the following aspects of documents:

Miss Leslie had started at Walgreens a few years earlier as a three-week temp in the purchasing department, but she had managed to turn that into a permanent job as Charles Walgreen Sr s personal receptionist, earning accolades for her ability to handle all comers with aplomb A good example: One day in 1933 a man carrying a revolver walked up to her desk and asked to see her boss Leslie assessed the situation, then calmly replied, Sir, Mr Walgreen is busy now, so you ll have to take a seat on the waiting room bench with the other gentlemen who are waiting and take your turn 42 Perhaps soothed by Leslie s smooth demeanor, the troubled man, incredibly, did as instructed, affording Leslie the opportunity to tell Mr Walgreen about his unscheduled visitor Walgreen was as cool as his receptionist He picked up the phone and called for a security officer, who kindly escorted the man downstairs, where the police were waiting At Walgreen s request, no charges were filed Back when company headquarters was still a pretty compact space, it was inevitable that Chuck would meet the poised young receptionist The two hit it off and married in 1933 Two years later they gave birth to Charles III When Charles Sr laid eyes on his grandson for the first time, he exclaimed, That s my little corker! 43 A nickname was coined, and former CEO Cork Walgreen has carried it ever since Chuck worked his way up from opening stores to leasing real estate, working on the front lines of the company s never-ending quest to find a good corner He proved especially effective at renegotiating store leases, a vital skill during the Depression, as the Fortune story mentioned earlier had attested Chuck plied his craft mainly out West, in Utah, California, and Oregon, with a simple but effective approach: He persuaded the landlords to set the rent lower than the pre-Depression rates so the store could stay above water, but higher than the current market price so the landlord could keep making a profit Walgreen almost always got what he wanted, partly because the deal made sense for both parties, partly because he sought only a fair arrangement, and partly because of his engaging million dollar smile, as his dad put it.

164 %R 85 70 39 70 1 56 21 15 18 40 70 16 11 2 0 14 (02) 122 (25) 107 (28) 75 119 (08) 70 (08) 130 (26) 62 (09) 124 (18) 21 006 (006) 004 (001) 82 80 55 73 21 75 26 18 24 21 0 2 0000 (0005) 17 (02) 24 (03) 24 (02) 52 (02) 42 (01) 54 (12) 56 (02) 93 (02) 98 (06) 92 (01) 71 (01) 26 (01) 54 (04) Olive Oil (Model 20) Pe (SD) %R 90 87 72 82 63 76 50 52 33 42 22 16 13 14 Octanol (Model 30) Pe (SD) %R Dodecane (Model 40) Pe (SD) 28 (12) 127 (16) 119 (10) 68 (14) 28 (02) 85 (30) 97 (01) 011 (003) 76 (01) 129 (11) 20 (01) 11 (01) 0000 (0005) 001 (001) %R 89 23 28 67 10 55 10 10 11 9 6 4 2 2

2%DOPC (Model 10) Pe (SD)

Make human-error security violations difficult through automation and configuration of security systems Do not make security procedures so complicated, difficult to adapt to, and time-consuming that people find ways to bypass them in daily operations

Chlorpromazine Phenazopyridine Verapamil Promethazine Quinine Imipramine Diltiazem Prazosin Propranolol Desipramine Primaquine Alprenolol Metoprolol Ranitidine Amiloride